InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Specc1l

Summary

InnateDB Protein

IDBP-162503.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Specc1l

Protein Name

sperm antigen with calponin homology and coiled-coil domains 1-like

Synonyms

4930470P14Rik; 4932439K10Rik; 9530057A13Rik; AI317249; Cytsa; mKIAA0376;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000045099

InnateDB Gene

IDBG-162501 (Specc1l)

Protein Structure

UniProt Annotation

Function

Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000269PubMed:21703590}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cell junction, gap junction {ECO:0000250}. Note=Colocalizes with beta-tubulin, acetylated alpha-tubulin and F-actin. Also observed in a ring around gamma-tubulin containing centrioles possibly in the microtubule organizing center (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0007026	negative regulation of microtubule depolymerization
GO:0007049	cell cycle
GO:0007155	cell adhesion
GO:0016477	cell migration
GO:0030036	actin cytoskeleton organization
GO:0030835	negative regulation of actin filament depolymerization
GO:0051301	cell division
GO:0060325	face morphogenesis

Cellular Component

GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0005819	spindle
GO:0005921	gap junction
GO:0015629	actin cytoskeleton
GO:0015630	microtubule cytoskeleton
GO:0031941	filamentous actin

Protein Structure and Domains

PDB ID

MGI:1921642

InterPro

IPR001715 Calponin homology domain
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain

PFAM

PF00307
PF00010
PF11971

PRINTS

PIRSF

SMART

SM00033
SM00353

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q2KN98