Version 5.4
Mus musculus Protein: Gdpd2
Summary
InnateDB Protein IDBP-162558.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gdpd2
Protein Name glycerophosphodiester phosphodiesterase domain containing 2
Synonyms 9130017L10Rik; Gde3; Obdpf;
Species Mus musculus
Ensembl Protein ENSMUSP00000019503
InnateDB Gene IDBG-162556 (Gdpd2)
Protein Structure
UniProt Annotation
Function Has glycerophosphoinositol inositolphosphodiesterase activity and specifically hydrolyzes glycerophosphoinositol, with no activity for other substrates such as glycerophosphoinositol 4- phosphate, glycerophosphocholine, glycerophosphoethanolamine, and glycerophosphoserine. Accelerates the program of osteoblast differentiation and growth. May play a role in remodeling of the actin cytoskeleton. {ECO:0000269PubMed:12933806, ECO:0000269PubMed:19596859}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:12933806}; Multi-pass membrane protein {ECO:0000269PubMed:12933806}. Cytoplasm {ECO:0000269PubMed:12933806}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:12933806}. Note=Colocalizes with the actin cytoskeleton.
Disease Associations
Tissue Specificity Detected in spleen, femur and calvaria. {ECO:0000269PubMed:12933806, ECO:0000269PubMed:15276213}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008081 phosphoric diester hydrolase activity
GO:0008889 glycerophosphodiester phosphodiesterase activity
GO:0046872 metal ion binding
GO:0047394 glycerophosphoinositol inositolphosphodiesterase activity
Biological Process
GO:0006071 glycerol metabolic process
GO:0006629 lipid metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1918834
InterPro IPR004129 Glycerophosphoryl diester phosphodiesterase
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9ESM6
PhosphoSite PhosphoSite-Q9ESM6
TrEMBL
UniProt Splice Variant
Entrez Gene 71584
UniGene Mm.283495
RefSeq NP_076097
MGI ID
MGI Symbol Gdpd2
OMIM
CCDS CCDS30306
HPRD
IMGT
EMBL AB048364 AK018634 BC038274
GenPept AAH38274 BAB13351 BAB31318

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca