InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Myh6

Summary

InnateDB Protein

IDBP-162611.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myh6

Protein Name

myosin, heavy polypeptide 6, cardiac muscle, alpha

Synonyms

A830009F23Rik; AA517445; alpha-MHC; Myhc-a; Myhca;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000080538

InnateDB Gene

IDBG-162609 (Myh6)

Protein Structure

UniProt Annotation

Function

Muscle contraction.

Subcellular Localization

Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0008307	structural constituent of muscle
GO:0016887	ATPase activity
GO:0019901	protein kinase binding
GO:0030898	actin-dependent ATPase activity
GO:0051015	actin filament binding

Biological Process

GO:0001701	in utero embryonic development
GO:0002026	regulation of the force of heart contraction
GO:0002027	regulation of heart rate
GO:0006200	ATP catabolic process
GO:0006936	muscle contraction
GO:0006941	striated muscle contraction
GO:0007512	adult heart development
GO:0007522	visceral muscle development
GO:0008016	regulation of heart contraction
GO:0008217	regulation of blood pressure
GO:0030048	actin filament-based movement
GO:0030049	muscle filament sliding
GO:0030239	myofibril assembly
GO:0030509	BMP signaling pathway
GO:0043462	regulation of ATPase activity
GO:0045214	sarcomere organization
GO:0048739	cardiac muscle fiber development
GO:0055009	atrial cardiac muscle tissue morphogenesis
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0060070	canonical Wnt signaling pathway
GO:0060420	regulation of heart growth

Cellular Component

GO:0001725	stress fiber
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005925	focal adhesion
GO:0016459	myosin complex
GO:0030016	myofibril
GO:0030018	Z disc
GO:0032982	myosin filament

Protein Structure and Domains

PDB ID

MGI:97255

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR000533 Tropomyosin
IPR001609 Myosin head, motor domain
IPR002928 Myosin tail
IPR004009 Myosin, N-terminal, SH3-like
IPR009053 Prefoldin
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF00261
PF12718
PF00063
PF01576
PF02736

PRINTS

PR00194
PR00193

PIRSF

SMART

SM00015
SM00242

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt