InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dlg3

Summary

InnateDB Protein

IDBP-162706.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dlg3

Protein Name

discs, large homolog 3 (Drosophila)

Synonyms

Dlgh3; mKIAA1232; SAP102;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000085299

InnateDB Gene

IDBG-162702 (Dlg3)

Protein Structure

UniProt Annotation

Function

Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0019902	phosphatase binding
GO:0019903	protein phosphatase binding
GO:0019904	protein domain specific binding
GO:0030165	PDZ domain binding
GO:0031625	ubiquitin protein ligase binding
GO:0035255	ionotropic glutamate receptor binding

Biological Process

GO:0001736	establishment of planar polarity
GO:0010923	negative regulation of phosphatase activity
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005923	tight junction
GO:0030426	growth cone
GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0043025	neuronal cell body
GO:0043198	dendritic shaft
GO:0045202	synapse

Protein Structure and Domains

PDB ID

MGI:1888986

InterPro

IPR001452 SH3 domain
IPR001478 PDZ domain
IPR008144 Guanylate kinase-like
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR011511 Variant SH3 domain
IPR016313 Disks large 1
IPR019583 PDZ-associated domain of NMDA receptors
IPR019590 Membrane-associated guanylate kinase (MAGUK), PEST domain, N-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM