InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lmx1b

Summary

InnateDB Protein

IDBP-162709.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lmx1b

Protein Name

LIM homeobox transcription factor 1 beta

Synonyms

LMX1.1; LMX1.2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043616

InnateDB Gene

IDBG-162707 (Lmx1b)

Protein Structure

UniProt Annotation

Function

Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001764	neuron migration
GO:0002930	trabecular meshwork development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0008283	cell proliferation
GO:0009953	dorsal/ventral pattern formation
GO:0010468	regulation of gene expression
GO:0021587	cerebellum morphogenesis
GO:0021954	central nervous system neuron development
GO:0030182	neuron differentiation
GO:0030199	collagen fibril organization
GO:0030326	embryonic limb morphogenesis
GO:0030901	midbrain development
GO:0035108	limb morphogenesis
GO:0035265	organ growth
GO:0043010	camera-type eye development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071542	dopaminergic neuron differentiation