InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Timm50

Summary

InnateDB Protein

IDBP-162753.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Timm50

Protein Name

translocase of inner mitochondrial membrane 50 homolog (yeast)

Synonyms

2810403L02Rik; AU015082; TIM50L;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000080614

InnateDB Gene

IDBG-162751 (Timm50)

Protein Structure

UniProt Annotation

Function

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. {ECO:0000250}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	55 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0005134	interleukin-2 receptor binding
GO:0005515	protein binding
GO:0043021	ribonucleoprotein complex binding

Biological Process

GO:0001836	release of cytochrome c from mitochondria
GO:0006470	protein dephosphorylation
GO:0007006	mitochondrial membrane organization
GO:0015031	protein transport
GO:0035335	peptidyl-tyrosine dephosphorylation

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005744	mitochondrial inner membrane presequence translocase complex
GO:0016021	integral component of membrane
GO:0016607	nuclear speck