InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Timm21

Summary

InnateDB Protein

IDBP-162802.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Timm21

Protein Name

RIKEN cDNA 1700034H14 gene

Synonyms

1700034H14Rik; 2700002I20Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025547

InnateDB Gene

IDBG-162800 (Timm21)

Protein Structure

UniProt Annotation

Function

Participates in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex. TIM21 probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0030150	protein import into mitochondrial matrix
GO:0032981	mitochondrial respiratory chain complex I assembly
GO:0033617	mitochondrial respiratory chain complex IV assembly