InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Drd2

Summary

InnateDB Protein

IDBP-162805.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Drd2

Protein Name

dopamine receptor D2

Synonyms

D2R; Drd-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000075170

InnateDB Gene

IDBG-162803 (Drd2)

Protein Structure

UniProt Annotation

Function

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Isoform 1 and isoform 2 are expressed in the pituitary and brain. Isoform 1 is expressed seven times more than isoform 2 in the caudate nucleus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0004930	G-protein coupled receptor activity
GO:0004952	dopamine receptor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008144	drug binding
GO:0035240	dopamine binding
GO:0035255	ionotropic glutamate receptor binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001659	temperature homeostasis
GO:0001666	response to hypoxia
GO:0001963	synaptic transmission, dopaminergic
GO:0001964	startle response
GO:0001975	response to amphetamine
GO:0001976	neurological system process involved in regulation of systemic arterial blood pressure
GO:0002027	regulation of heart rate
GO:0002028	regulation of sodium ion transport
GO:0002031	G-protein coupled receptor internalization
GO:0002052	positive regulation of neuroblast proliferation
GO:0002092	positive regulation of receptor internalization
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007212	dopamine receptor signaling pathway
GO:0007270	neuron-neuron synaptic transmission
GO:0007409	axonogenesis
GO:0007416	synapse assembly
GO:0007608	sensory perception of smell
GO:0007616	long-term memory
GO:0007625	grooming behavior
GO:0007626	locomotory behavior
GO:0007628	adult walking behavior
GO:0007631	feeding behavior
GO:0008104	protein localization
GO:0008285	negative regulation of cell proliferation
GO:0008306	associative learning
GO:0008542	visual learning
GO:0009416	response to light stimulus
GO:0009636	response to toxic substance
GO:0010039	response to iron ion
GO:0014059	regulation of dopamine secretion
GO:0014854	response to inactivity
GO:0016055	Wnt signaling pathway
GO:0021756	striatum development
GO:0021769	orbitofrontal cortex development
GO:0021853	cerebral cortex GABAergic interneuron migration
GO:0021984	adenohypophysis development
GO:0030336	negative regulation of cell migration
GO:0030432	peristalsis
GO:0030534	adult behavior
GO:0030814	regulation of cAMP metabolic process
GO:0030900	forebrain development
GO:0031223	auditory behavior
GO:0032147	activation of protein kinase activity
GO:0032228	regulation of synaptic transmission, GABAergic
GO:0032467	positive regulation of cytokinesis
GO:0032922	circadian regulation of gene expression
GO:0033602	negative regulation of dopamine secretion
GO:0034776	response to histamine
GO:0035094	response to nicotine
GO:0035556	intracellular signal transduction
GO:0035810	positive regulation of urine volume
GO:0035815	positive regulation of renal sodium excretion
GO:0040018	positive regulation of multicellular organism growth
GO:0042220	response to cocaine
GO:0042321	negative regulation of circadian sleep/wake cycle, sleep
GO:0042417	dopamine metabolic process
GO:0042493	response to drug
GO:0043266	regulation of potassium ion transport
GO:0043278	response to morphine
GO:0043408	regulation of MAPK cascade
GO:0043473	pigmentation
GO:0043666	regulation of phosphoprotein phosphatase activity
GO:0045087	innate immune response (InnateDB)
GO:0045471	response to ethanol
GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway
GO:0045776	negative regulation of blood pressure
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046488	phosphatidylinositol metabolic process
GO:0046676	negative regulation of insulin secretion
GO:0046717	acid secretion
GO:0048148	behavioral response to cocaine
GO:0048149	behavioral response to ethanol
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0048678	response to axon injury
GO:0048755	branching morphogenesis of a nerve
GO:0050482	arachidonic acid secretion
GO:0050709	negative regulation of protein secretion
GO:0050804	regulation of synaptic transmission
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051481	negative regulation of cytosolic calcium ion concentration
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051584	regulation of dopamine uptake involved in synaptic transmission
GO:0051586	positive regulation of dopamine uptake involved in synaptic transmission
GO:0051823	regulation of synapse structural plasticity
GO:0051898	negative regulation of protein kinase B signaling
GO:0051967	negative regulation of synaptic transmission, glutamatergic
GO:0060124	positive regulation of growth hormone secretion
GO:0060134	prepulse inhibition
GO:0060158	phospholipase C-activating dopamine receptor signaling pathway
GO:0060160	negative regulation of dopamine receptor signaling pathway
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0090325	regulation of locomotion involved in locomotory behavior
GO:1900273	positive regulation of long-term synaptic potentiation
GO:1901386	negative regulation of voltage-gated calcium channel activity

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016328	lateral plasma membrane
GO:0030139	endocytic vesicle
GO:0030424	axon
GO:0030425	dendrite
GO:0030672	synaptic vesicle membrane
GO:0031410	cytoplasmic vesicle
GO:0036126	sperm flagellum
GO:0043197	dendritic spine
GO:0043204	perikaryon
GO:0043679	axon terminus

Protein Structure and Domains

PDB ID

MGI:94924

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000929 Dopamine receptor family
IPR001922 Dopamine D2 receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00242
PR00567

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P61168