InnateDB Protein
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IDBP-162817.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ifne
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Protein Name
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interferon epsilon
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000059199
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InnateDB Gene
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IDBG-162815 (Ifne)
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Protein Structure
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Function |
Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral, including HSV-2, and bacterial, including Chlamydia muridarum, genital infections. {ECO:0000269PubMed:23449591}.
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Subcellular Localization |
Secreted {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expressed at very high levels in uterus and, at much lower levels, in ovary and cervix. Very low levels, if any, in other organs. In the endometrium, expressed in the luminal and glandular epithelial cells (at protein level). {ECO:0000269PubMed:15233997, ECO:0000269PubMed:23449591}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2667156
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InterPro |
IPR000471
Interferon alpha/beta/delta
IPR009079
Four-helical cytokine-like, core
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PFAM |
PF00143
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PRINTS |
PR00266
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PIRSF |
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SMART |
SM00076
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TIGRFAMs |
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Modification |
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SwissProt |
Q80ZF2
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
230405
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UniGene |
Mm.246593
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RefSeq |
NP_796322
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MGI ID |
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MGI Symbol |
Ifne
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OMIM |
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CCDS |
CCDS18348
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HPRD |
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IMGT |
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EMBL |
AL805899
AY190044
BC104376
BC104377
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GenPept |
AAI04377
AAI04378
AAO38685
CAM23377
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