InnateDB Protein
|
IDBP-162829.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Snrpd3
|
Protein Name
|
small nuclear ribonucleoprotein D3
|
Synonyms
|
1700043E15Rik; 2310009E13Rik; AW046420; SMD3;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000020397
|
InnateDB Gene
|
IDBG-162827 (Snrpd3)
|
Protein Structure
|
|
Function |
Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing.
|
Subcellular Localization |
Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 66 interaction(s) predicted by orthology.
Experimentally validated |
Total |
15
[view]
|
Protein-Protein |
15
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
66 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:1914582
|
InterPro |
IPR001163
Ribonucleoprotein LSM domain
IPR006649
Ribonucleoprotein LSM domain, eukaryotic/archaea-type
IPR010920
Like-Sm (LSM) domain
|
PFAM |
PF01423
|
PRINTS |
|
PIRSF |
|
SMART |
SM00651
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P62320
|
PhosphoSite |
PhosphoSite-P62320
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
67332
|
UniGene |
|
RefSeq |
NP_080371
|
MGI ID |
|
MGI Symbol |
Snrpd3
|
OMIM |
|
CCDS |
CCDS23926
|
HPRD |
|
IMGT |
|
EMBL |
AK005341
AK006692
AK019453
AK160321
|
GenPept |
BAB23963
BAB24705
BAB31729
BAE35738
|
|
|