InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Crtc1

Summary

InnateDB Protein

IDBP-162962.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Crtc1

Protein Name

CREB regulated transcription coactivator 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000075916

InnateDB Gene

IDBG-162960 (Crtc1)

Protein Structure

UniProt Annotation

Function

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells (By similarity). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons. {ECO:0000250, ECO:0000269PubMed:17360587}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:17360587}. Nucleus {ECO:0000269PubMed:17360587}. Note=Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins (By similarity). Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in specific regions of the brain including the cortex, hippocampus and striatum. {ECO:0000269PubMed:17360587}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008140	cAMP response element binding protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007613	memory
GO:0032793	positive regulation of CREB transcription factor activity
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051289	protein homotetramerization
GO:0060081	membrane hyperpolarization