InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCDC88C

Summary

InnateDB Protein

IDBP-16299.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCDC88C

Protein Name

coiled-coil domain containing 88C

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000374507

InnateDB Gene

IDBG-16295 (CCDC88C)

Protein Structure

UniProt Annotation

Function

Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit CTNNB1/Beta-catenin stabilization. {ECO:0000250UniProtKB:Q6VGS5}.

Subcellular Localization

Disease Associations

Hydrocephalus, non-syndromic, autosomal recessive 1 (HYC1) [MIM:236600]: A disease characterized by a disturbance of cerebrospinal fluid circulation causing accumulation of ventricular cerebrospinal fluid, which results in progressive ventricular dilatation with onset in utero. Affected individuals may have neurologic impairment. {ECO:0000269PubMed:21031079, ECO:0000269PubMed:23042809}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0030165	PDZ domain binding
GO:0043621	protein self-association

Biological Process

GO:0001932	regulation of protein phosphorylation
GO:0016055	Wnt signaling pathway
GO:0031648	protein destabilization
GO:0051260	protein homooligomerization
GO:0055114	oxidation-reduction process