InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mat2b

Summary

InnateDB Protein

IDBP-163160.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mat2b

Protein Name

methionine adenosyltransferase II, beta

Synonyms

1110064C04Rik; 2410018D16Rik; AI182287; AU022853; MAT-II; MATIIbeta; TGR;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000098901

InnateDB Gene

IDBG-163156 (Mat2b)

Protein Structure

UniProt Annotation

Function

Non-catalytic regulatory subunit of S-adenosylmethionine synthetase 2 (MAT2A), an enzyme that catalyzes the formation of S- adenosylmethionine from methionine and ATP. Regulates the activity of S-adenosylmethionine synthetase 2 by changing its kinetic properties, rendering the enzyme more susceptible to S- adenosylmethionine inhibition.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0008831	dTDP-4-dehydrorhamnose reductase activity
GO:0019899	enzyme binding
GO:0048270	methionine adenosyltransferase regulator activity
GO:0050662	coenzyme binding

Biological Process

GO:0006556	S-adenosylmethionine biosynthetic process
GO:0006730	one-carbon metabolic process
GO:0009058	biosynthetic process
GO:0044237	cellular metabolic process
GO:0045226	extracellular polysaccharide biosynthetic process
GO:0050790	regulation of catalytic activity
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0048269	methionine adenosyltransferase complex

Protein Structure and Domains

PDB ID

MGI:1913667

InterPro

IPR001509 NAD-dependent epimerase/dehydratase
IPR003869 Polysaccharide biosynthesis protein, CapD-like domain
IPR005913 dTDP-4-dehydrorhamnose reductase

PFAM

PF01370
PF02719
PF04321

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99LB6

PhosphoSite