Version 5.4
Mus musculus Protein: Gcsam
Summary
InnateDB Protein IDBP-163211.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gcsam
Protein Name germinal center expressed transcript 2
Synonyms Gcet; Gcet2; M17; M17-L;
Species Mus musculus
Ensembl Protein ENSMUSP00000023339
InnateDB Gene IDBG-163209 (Gcsam)
Protein Structure
UniProt Annotation
Function Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=It relocalizes from the cytoplasm to podosome- like structures upon cell treatment with IL6. {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in normal germinal center (GC) B-cells. Expressed in spleen and, to a lesser extent, bone marrow. {ECO:0000269PubMed:7981148, ECO:0000269Ref.2}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0019901 protein kinase binding
GO:0045159 myosin II binding
Biological Process
GO:0050855 regulation of B cell receptor signaling pathway
GO:2000402 negative regulation of lymphocyte migration
Cellular Component
GO:0005739 mitochondrion
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:102969
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6RFH4
PhosphoSite PhosphoSite-Q6RFH4
TrEMBL
UniProt Splice Variant
Entrez Gene 14525
UniGene Mm.4799
RefSeq NP_032125
MGI ID
MGI Symbol Gcsam
OMIM
CCDS CCDS28199
HPRD
IMGT
EMBL AK036553 AY500830 BC099585 U13263
GenPept AAA96821 AAH99585 AAR89181 BAC29474

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca