InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Jph4

Summary

InnateDB Protein

IDBP-163216.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Jph4

Protein Name

junctophilin 4

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022819

InnateDB Gene

IDBG-163214 (Jph4)

Protein Structure

UniProt Annotation

Function

Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory. {ECO:0000269PubMed:16809425}.

Subcellular Localization

Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000269PubMed:16809425}; Single-pass type IV membrane protein {ECO:0000269PubMed:16809425}. Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Specifically expressed in brain. Highest levels in the olfactory tubercle, caudate putamen, nucleus accumbens, hippocampal formation, piriform cortex and cerebellar cortex. Expressed in disctete neurons sites. In hippocampal formation, expressed in dendrites of hippocampal pyramidal and denate granule cells. In cerebellum, it is highly expressed in Purkinje cells, while it is weakly expressed in granular cells. {ECO:0000269PubMed:14559359, ECO:0000269PubMed:16809425}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0007612	learning
GO:0048167	regulation of synaptic plasticity
GO:0050885	neuromuscular process controlling balance

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0005790	smooth endoplasmic reticulum
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0043198	dendritic shaft