InnateDB Protein
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IDBP-16326.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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THOP1
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Protein Name
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thimet oligopeptidase 1
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Synonyms
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EP24.15; MEPD_HUMAN; MP78; TOP;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000304467
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InnateDB Gene
|
IDBG-16324 (THOP1)
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Protein Structure
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|
Function |
Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the beta-amyloid precursor protein and generate amyloidogenic fragments.
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Subcellular Localization |
Cytoplasm.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
36
[view]
|
Protein-Protein |
36
[view]
|
Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
|
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Predicted by orthology |
Total |
1 [view]
|
|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001567
Peptidase M3A/M3B
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PFAM |
PF01432
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PRINTS |
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PIRSF |
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SMART |
|
TIGRFAMs |
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Modification |
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SwissProt |
P52888
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PhosphoSite |
PhosphoSite-P52888
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TrEMBL |
Q9BW75
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UniProt Splice Variant |
|
Entrez Gene |
7064
|
UniGene |
Hs.78769
|
RefSeq |
NP_003240
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HUGO |
HGNC:11793
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OMIM |
601117
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CCDS |
CCDS12095
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HPRD |
03072
|
IMGT |
|
EMBL |
AC006538
BC000135
BC000583
BC002391
U29366
Z50115
|
GenPept |
AAA82607
AAD13118
AAH00135
AAH00583
AAH02391
CAA90477
|
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