InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rab11fip5

Summary

InnateDB Protein

IDBP-163303.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rab11fip5

Protein Name

RAB11 family interacting protein 5 (class I)

Synonyms

9130206P09Rik; C75969; D6Ertd32e; GAF1; RIP11;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000058305

InnateDB Gene

IDBG-163299 (Rab11fip5)

Protein Structure

UniProt Annotation

Function

Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269PubMed:19335615}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Recycling endosome membrane {ECO:0000269PubMed:19335615}; Peripheral membrane protein {ECO:0000269PubMed:19335615}. Early endosome membrane {ECO:0000269PubMed:19335615}; Peripheral membrane protein {ECO:0000269PubMed:19335615}. Golgi apparatus membrane {ECO:0000269PubMed:19335615}; Peripheral membrane protein {ECO:0000269PubMed:19335615}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269PubMed:19335615}; Peripheral membrane protein {ECO:0000269PubMed:19335615}. Mitochondrion membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0043015	gamma-tubulin binding

Biological Process

GO:0015031	protein transport
GO:0035773	insulin secretion involved in cellular response to glucose stimulus
GO:0045055	regulated secretory pathway
GO:0071468	cellular response to acidity
GO:2000008	regulation of protein localization to cell surface

Cellular Component

GO:0000139	Golgi membrane
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005769	early endosome
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005815	microtubule organizing center
GO:0030141	secretory granule
GO:0030658	transport vesicle membrane
GO:0031901	early endosome membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0055037	recycling endosome
GO:0055038	recycling endosome membrane