InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dhrs4

Summary

InnateDB Protein

IDBP-163331.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dhrs4

Protein Name

dehydrogenase/reductase (SDR family) member 4

Synonyms

AI043103; AI790593; CR; D14Ucla2; mouNRDR; NDRD; PHCR; PSCD; RRD;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022821

InnateDB Gene

IDBG-163329 (Dhrs4)

Protein Structure

UniProt Annotation

Function

Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co- factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). {ECO:0000250}.

Subcellular Localization

Peroxisome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001758	retinal dehydrogenase activity
GO:0004090	carbonyl reductase (NADPH) activity
GO:0016491	oxidoreductase activity

Biological Process

GO:0008152	metabolic process
GO:0042574	retinal metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005777	peroxisome

Protein Structure and Domains

PDB ID

MGI:90169

InterPro

IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR002424 Alcohol dehydrogenase, insect-type
IPR003560 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
IPR013968 Polyketide synthase, KR

PFAM

PF00106
PF08659

PRINTS

PR00080
PR00081
PR01167
PR01397

PIRSF

PIRSF000126

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt