Version 5.4
Mus musculus Protein: Ccng1
Summary
InnateDB Protein IDBP-163401.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ccng1
Protein Name cyclin G1
Synonyms AI314029;
Species Mus musculus
Ensembl Protein ENSMUSP00000020576
InnateDB Gene IDBG-163399 (Ccng1)
Protein Structure
UniProt Annotation
Function May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation. {ECO:0000269PubMed:8887688, ECO:0000269PubMed:9696022}.
Subcellular Localization Nucleus {ECO:0000269PubMed:9696022}.
Disease Associations
Tissue Specificity Highest levels in kidney, heart and skeletal muscle.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019904 protein domain specific binding
Biological Process
GO:0006949 syncytium formation
GO:0007067 mitotic nuclear division
GO:0007095 mitotic G2 DNA damage checkpoint
GO:0007420 brain development
GO:0010243 response to organonitrogen compound
GO:0016049 cell growth
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:102890
InterPro IPR006671 Cyclin, N-terminal
IPR013763 Cyclin-like
PFAM PF00134
PRINTS
PIRSF
SMART SM00385
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P51945
PhosphoSite PhosphoSite-P51945
TrEMBL Q6LC40
UniProt Splice Variant
Entrez Gene 12450
UniGene Mm.395921
RefSeq NP_033961
MGI ID
MGI Symbol Ccng1
OMIM
CCDS CCDS24550
HPRD
IMGT
EMBL AB005559 AK143114 AK147026 AK159831 AK167486 CH466609 L49507 U87998 Z37110
GenPept AAB83957 AAC42082 BAA24492 BAE25273 BAE27619 BAE35410 BAE39566 CAA85474 EDL32333

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca