InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Noto

Summary

InnateDB Protein

IDBP-163404.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Noto

Protein Name

notochord homolog (Xenopus laevis)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000087006

InnateDB Gene

IDBG-163402 (Noto)

Protein Structure

UniProt Annotation

Function

Transcription regulator acting downstream of both FOXA2 and T during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate. {ECO:0000269PubMed:15231714, ECO:0000269PubMed:17884984, ECO:0000269PubMed:18061569}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.

Disease Associations

Note=Defects in Noto are the cause of the truncate (tc) phenotype. Truncate (tc) is a recessive mutation that affects the development of the caudal notochord. Mice homozygous for tc are viable but viability is reduced, which is attributed at least in part to spinal injury in the sacral and lower lumbar region.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007368	determination of left/right symmetry
GO:0009880	embryonic pattern specification
GO:0009953	dorsal/ventral pattern formation
GO:0030903	notochord development
GO:0060271	cilium morphogenesis