InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ell

Summary

InnateDB Protein

IDBP-163431.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ell

Protein Name

elongation factor RNA polymerase II

Synonyms

Ell1; Men;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000091163

InnateDB Gene

IDBG-163429 (Ell)

Protein Structure

UniProt Annotation

Function

Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre- initiation complex and early elongation. Specifically required for stimulating the elongation step of RNA polymerase II- and III- dependent snRNA gene transcription (By similarity). Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). {ECO:0000250, ECO:0000269PubMed:22195968}.

Subcellular Localization

Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}. Nucleus, Cajal body {ECO:0000250}. Note=Colocalizes with EAF2 to nuclear speckles. Colocalizes with coilin in subnuclear cajal and histone locus bodies. Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019902	phosphatase binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006355	regulation of transcription, DNA-templated
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0010923	negative regulation of phosphatase activity