InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APOBEC1

Summary

InnateDB Protein

IDBP-16346.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APOBEC1

Protein Name

apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1

Synonyms

APOBEC-1; BEDP; CDAR1; HEPR;

Species

Homo sapiens

Ensembl Protein

ENSP00000229304

InnateDB Gene

IDBG-16344 (APOBEC1)

Protein Structure

UniProt Annotation

Function

Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. {ECO:0000269PubMed:11727199}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:22580899}.

Disease Associations

Tissue Specificity

Expressed exclusively in the small intestine.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003824	catalytic activity
GO:0004126	cytidine deaminase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
GO:0017091	AU-rich element binding

Biological Process

GO:0006396	RNA processing
GO:0006397	mRNA processing
GO:0006629	lipid metabolic process
GO:0006970	response to osmotic stress
GO:0009972	cytidine deamination
GO:0010043	response to zinc ion
GO:0010332	response to gamma radiation
GO:0010467	gene expression
GO:0016554	cytidine to uridine editing
GO:0016556	mRNA modification
GO:0032869	cellular response to insulin stimulus
GO:0042127	regulation of cell proliferation
GO:0042157	lipoprotein metabolic process
GO:0042158	lipoprotein biosynthetic process
GO:0042493	response to drug
GO:0042953	lipoprotein transport
GO:0045471	response to ethanol
GO:0048255	mRNA stabilization
GO:0051592	response to calcium ion
GO:0051607	defense response to virus
GO:0080111	DNA demethylation
GO:0090310	negative regulation of methylation-dependent chromatin silencing