InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ift74

Summary

InnateDB Protein

IDBP-163513.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ift74

Protein Name

intraflagellar transport 74 homolog (Chlamydomonas)

Synonyms

1700029H06Rik; b2b796Clo; Ccdc2; Cmg1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030311

InnateDB Gene

IDBG-163511 (Ift74)

Protein Structure

UniProt Annotation

Function

Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis (By similarity). {ECO:0000250}.

Subcellular Localization

Cell projection, cilium {ECO:0000269PubMed:16775004}. Cytoplasmic vesicle {ECO:0000250}. Note=Intracellular vesicular compartment. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0048487	beta-tubulin binding

Biological Process

GO:0003334	keratinocyte development
GO:0007219	Notch signaling pathway
GO:0008544	epidermis development
GO:0033630	positive regulation of cell adhesion mediated by integrin
GO:0035735	intraciliary transport involved in cilium morphogenesis
GO:0042073	intraciliary transport
GO:0042384	cilium assembly
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050680	negative regulation of epithelial cell proliferation
GO:0060271	cilium morphogenesis