InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Smcr7l

Summary

InnateDB Protein

IDBP-163544.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smcr7l

Protein Name

Smith-Magenis syndrome chromosome region, candidate 7-like (human)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023048

InnateDB Gene

IDBG-163542 (Smcr7l)

Protein Structure

UniProt Annotation

Function

Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L. {ECO:0000269PubMed:23283981, ECO:0000269PubMed:24508339}.

Subcellular Localization

Mitochondrion outer membrane {ECO:0000269PubMed:24508339}; Single-pass membrane protein {ECO:0000269PubMed:24508339}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0019003	GDP binding
GO:0042802	identical protein binding
GO:0043531	ADP binding