Version 5.4
Mus musculus Protein: Phldb2
Summary
InnateDB Protein IDBP-163591.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Phldb2
Protein Name pleckstrin homology-like domain, family B, member 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000046496
InnateDB Gene IDBG-163589 (Phldb2)
Protein Structure
UniProt Annotation
Function Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane. {ECO:0000269PubMed:15851520}.
Subcellular Localization Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Translocates to the plasma membrane at high levels of PtdIns(3,4,5)P3. At low levels of PtdIns(3,4,5)P3 is translocated to vesicular compartments (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed at postsynaptic membranes of skeletal neuromuscular junctions (at protein level). {ECO:0000269PubMed:15851520}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0045111 intermediate filament cytoskeleton
Protein Structure and Domains
PDB ID MGI:2444981
InterPro IPR001849 Pleckstrin homology domain
PFAM PF00169
PRINTS
PIRSF
SMART SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K1N2
PhosphoSite PhosphoSite-Q8K1N2
TrEMBL
UniProt Splice Variant
Entrez Gene 208177
UniGene Mm.420805
RefSeq NP_700461
MGI ID
MGI Symbol Phldb2
OMIM
CCDS CCDS28202
HPRD
IMGT
EMBL AF506821 AK049595 AK165251 BC050915 BC060683
GenPept AAH50915 AAH60683 AAM33635 BAC33833 BAE38105

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca