InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lrfn1

Summary

InnateDB Protein

IDBP-163601.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lrfn1

Protein Name

leucine rich repeat and fibronectin type III domain containing 1

Synonyms

BC004018; SALM2; Semo1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000057645

InnateDB Gene

IDBG-163599 (Lrfn1)

Protein Structure

UniProt Annotation

Function

Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1. {ECO:0000269PubMed:16828986, ECO:0000269PubMed:18585462}.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Detected in excitatory, but not inhibitory, synaptic plasma membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Predominantly expressed in the brain, with a weak, but broad expression in the cerebral cortex and diencephalic nuclei. Also detected in other parts of the central nervous system, including the olfactory bulb, pons, cerebellum, and medulla oblongata, as well as in the peripheral nervous system, such as the ganglia of cranial nerves and the dorsal root ganglion during gestation. {ECO:0000269PubMed:16828986}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

Cellular Component

GO:0014069	postsynaptic density
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:2136810

InterPro

IPR000483 Cysteine-rich flanking region, C-terminal
IPR003591 Leucine-rich repeat, typical subtype
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin

PFAM

PF01463
PF00041
PF01108
PF07679
PF00047

PRINTS

PIRSF

SMART

SM00082
SM00369
SM00408
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q2WF71