InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Phf19

Summary

InnateDB Protein

IDBP-163634.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Phf19

Protein Name

PHD finger protein 19

Synonyms

3110009G19Rik; 3321402G02Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028232

InnateDB Gene

IDBG-163632 (Phf19)

Protein Structure

UniProt Annotation

Function

Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases NO66 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds dimethylated at 'Lys- 36' (H3K36me2). {ECO:0000269PubMed:22438827, ECO:0000269PubMed:23104054, ECO:0000269PubMed:23160351, ECO:0000269PubMed:23273982}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0035064	methylated histone binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0016568	chromatin modification
GO:0019827	stem cell maintenance
GO:0048863	stem cell differentiation
GO:0061087	positive regulation of histone H3-K27 methylation