InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dlat

Summary

InnateDB Protein

IDBP-163714.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dlat

Protein Name

dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034567

InnateDB Gene

IDBG-163712 (Dlat)

Protein Structure

UniProt Annotation

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000250}.

Subcellular Localization

Mitochondrion matrix.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004742	dihydrolipoyllysine-residue acetyltransferase activity
GO:0005515	protein binding
GO:0016746	transferase activity, transferring acyl groups

Biological Process

GO:0006006	glucose metabolic process
GO:0006086	acetyl-CoA biosynthetic process from pyruvate
GO:0006090	pyruvate metabolic process
GO:0006099	tricarboxylic acid cycle
GO:0008152	metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005967	mitochondrial pyruvate dehydrogenase complex
GO:0045254	pyruvate dehydrogenase complex

Protein Structure and Domains

PDB ID

MGI:2385311

InterPro

IPR000089 Biotin/lipoyl attachment
IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain
IPR004167 E3 binding
IPR006257 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
IPR011053 Single hybrid motif

PFAM

PF00364
PF00198
PF02817

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BMF4

PhosphoSite