InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sod3

Summary

InnateDB Protein

IDBP-163720.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sod3

Protein Name

superoxide dismutase 3, extracellular

Synonyms

AI314465; EC-SOD;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000098768

InnateDB Gene

IDBG-163718 (Sod3)

Protein Structure

UniProt Annotation

Function

Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen. {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004784	superoxide dismutase activity
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0001666	response to hypoxia
GO:0006801	superoxide metabolic process
GO:0006979	response to oxidative stress
GO:0019430	removal of superoxide radicals
GO:0046688	response to copper ion
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005796	Golgi lumen
GO:0005802	trans-Golgi network
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome