Version 5.4
Mus musculus Protein: Egr4
Summary
InnateDB Protein IDBP-163723.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Egr4
Protein Name early growth response 4
Synonyms NGF1-C; NGFI-C; NGFIC; pAT133;
Species Mus musculus
Ensembl Protein ENSMUSP00000093433
InnateDB Gene IDBG-163721 (Egr4)
Protein Structure
UniProt Annotation
Function Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0043066 negative regulation of apoptotic process
GO:0071320 cellular response to cAMP
GO:0071371 cellular response to gonadotropin stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:99252
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WUF2
PhosphoSite PhosphoSite-
TrEMBL Q3URA9
UniProt Splice Variant
Entrez Gene 13656
UniGene Mm.44137
RefSeq NP_065621
MGI ID
MGI Symbol Egr4
OMIM
CCDS CCDS20297
HPRD
IMGT
EMBL AF132613 AK141637
GenPept AAD28267 BAE24779

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca