Version 5.4
Mus musculus Protein: Efna3
Summary
InnateDB Protein IDBP-163797.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Efna3
Protein Name ephrin A3
Synonyms AW494418; EFL-2; Ehk1-L; Epl3; LERK-3;
Species Mus musculus
Ensembl Protein ENSMUSP00000029673
InnateDB Gene IDBG-163795 (Efna3)
Protein Structure
UniProt Annotation
Function Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. {ECO:0000269PubMed:9053851}.
Subcellular Localization Cell membrane; Lipid-anchor, GPI-anchor.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0046875 ephrin receptor binding
Biological Process
GO:0007411 axon guidance
GO:0045664 regulation of neuron differentiation
GO:0048013 ephrin receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031225 anchored component of membrane
Protein Structure and Domains
PDB ID MGI:106644
InterPro IPR001799 Ephrin
IPR008972 Cupredoxin
PFAM PF00812
PRINTS PR01347
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O08545
PhosphoSite PhosphoSite-O08545
TrEMBL Q9CRL3
UniProt Splice Variant
Entrez Gene 13638
UniGene Mm.458759
RefSeq NP_034238
MGI ID
MGI Symbol Efna3
OMIM
CCDS CCDS38488
HPRD
IMGT
EMBL AK020438 BC107002 BC125003 U90666 U92885
GenPept AAB50241 AAC39961 AAI07003 AAI25004 BAB32100

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca