InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cps1

Summary

InnateDB Protein

IDBP-163891.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cps1

Protein Name

carbamoyl-phosphate synthetase 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027144

InnateDB Gene

IDBG-163889 (Cps1)

Protein Structure

UniProt Annotation

Function

Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.

Subcellular Localization

Mitochondrion {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004087	carbamoyl-phosphate synthase (ammonia) activity
GO:0004175	endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005543	phospholipid binding
GO:0008716	D-alanine-D-alanine ligase activity
GO:0016595	glutamate binding
GO:0032403	protein complex binding
GO:0046872	metal ion binding
GO:0072341	modified amino acid binding

Biological Process

GO:0000050	urea cycle
GO:0001101	response to acid
GO:0001889	liver development
GO:0005980	glycogen catabolic process
GO:0006508	proteolysis
GO:0006543	glutamine catabolic process
GO:0006807	nitrogen compound metabolic process
GO:0007494	midgut development
GO:0008152	metabolic process
GO:0009636	response to toxic substance
GO:0010043	response to zinc ion
GO:0014075	response to amine
GO:0019433	triglyceride catabolic process
GO:0032094	response to food
GO:0032496	response to lipopolysaccharide
GO:0033762	response to glucagon
GO:0034201	response to oleic acid
GO:0042493	response to drug
GO:0042594	response to starvation
GO:0043200	response to amino acid
GO:0044344	cellular response to fibroblast growth factor stimulus
GO:0045909	positive regulation of vasodilation
GO:0046209	nitric oxide metabolic process
GO:0048545	response to steroid hormone
GO:0050667	homocysteine metabolic process
GO:0051384	response to glucocorticoid
GO:0051591	response to cAMP
GO:0055081	anion homeostasis
GO:0060416	response to growth hormone
GO:0070365	hepatocyte differentiation
GO:0070409	carbamoyl phosphate biosynthetic process
GO:0071320	cellular response to cAMP
GO:0071377	cellular response to glucagon stimulus
GO:0071400	cellular response to oleic acid
GO:0071548	response to dexamethasone

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0042645	mitochondrial nucleoid
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

MGI:891996

InterPro

IPR002474 Carbamoyl-phosphate synthase, small subunit N-terminal domain
IPR003135 ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type
IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
IPR005480 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain
IPR005481 Carbamoyl-phosphate synthase, large subunit, N-terminal
IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain
IPR006274 Carbamoyl-phosphate synthase, small subunit
IPR006275 Carbamoyl-phosphate synthase, large subunit
IPR011095 D-alanine--D-alanine ligase, C-terminal
IPR011607 Methylglyoxal synthase-like domain
IPR011761 ATP-grasp fold
IPR016185 Pre-ATP-grasp domain
IPR017926 Glutamine amidotransferase
IPR029062 Class I glutamine amidotransferase-like

PFAM