InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ifi30

Summary

InnateDB Protein

IDBP-164063.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ifi30

Protein Name

interferon gamma inducible protein 30

Synonyms

GILT; IP30;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034299

InnateDB Gene

IDBG-164061 (Ifi30)

Protein Structure

UniProt Annotation

Function

Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II- restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds. Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation. {ECO:0000269PubMed:11701933, ECO:0000269PubMed:18815593, ECO:0000269PubMed:20538950}.

Subcellular Localization

Secreted {ECO:0000250}. Lysosome {ECO:0000269PubMed:11701933}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015036	disulfide oxidoreductase activity
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors

Biological Process

GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0048147	negative regulation of fibroblast proliferation
GO:0050821	protein stabilization
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005886	plasma membrane
GO:0030054	cell junction
GO:0043231	intracellular membrane-bounded organelle