Version 5.4
Mus musculus Protein: Fitm1
Summary
InnateDB Protein IDBP-164087.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fitm1
Protein Name fat storage-inducing transmembrane protein 1
Synonyms 1110028A07Rik; AV010547; Cg10671; Fit1;
Species Mus musculus
Ensembl Protein ENSMUSP00000022826
InnateDB Gene IDBG-164085 (Fitm1)
Protein Structure
UniProt Annotation
Function Plays an important role in lipid droplet accumulation. {ECO:0000269PubMed:18160536}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:18160536}; Multi-pass membrane protein {ECO:0000269PubMed:18160536}.
Disease Associations
Tissue Specificity Predominantly expressed in skeletal muscle and at lower levels in the heart (at protein level). In the heart, mRNA expression levels do not correlate well with protein levels, suggesting post-transcriptional regulation in this organ. {ECO:0000269PubMed:18160536}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0010890 positive regulation of sequestering of triglyceride
GO:0034389 lipid particle organization
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0030176 integral component of endoplasmic reticulum membrane
Protein Structure and Domains
PDB ID MGI:1915930
InterPro IPR019388 Fat storage-inducing transmembrane protein
PFAM PF10261
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91V79
PhosphoSite PhosphoSite-Q91V79
TrEMBL
UniProt Splice Variant
Entrez Gene 68680
UniGene
RefSeq NP_081084
MGI ID
MGI Symbol Fitm1
OMIM
CCDS CCDS27116
HPRD
IMGT
EMBL AB053120 AB054000 AK003939 BC037188 BC048823 BC104408 BC104409
GenPept AAH37188 AAH48823 AAI04409 AAI04410 BAB23085 BAB47400 BAB47402

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca