InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pik3r2

Summary

InnateDB Protein

IDBP-164120.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pik3r2

Protein Name

phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)

Synonyms

p85beta;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034296

InnateDB Gene

IDBG-164118 (Pik3r2)

Protein Structure

UniProt Annotation

Function

Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 88 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	88 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016303	1-phosphatidylinositol-3-kinase activity
GO:0035014	phosphatidylinositol 3-kinase regulator activity

Biological Process

GO:0007165	signal transduction
GO:0008286	insulin receptor signaling pathway
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
GO:0042325	regulation of phosphorylation
GO:0043551	regulation of phosphatidylinositol 3-kinase activity

Cellular Component

GO:0005622	intracellular
GO:0005942	phosphatidylinositol 3-kinase complex

Protein Structure and Domains

PDB ID

MGI:1098772

InterPro

IPR000198 Rho GTPase-activating protein domain
IPR000980 SH2 domain
IPR001452 SH3 domain
IPR001720 PI3 kinase, P85 regulatory subunit
IPR008936 Rho GTPase activation protein

PFAM

PF00620
PF00017
PF14633
PF00018
PF14604

PRINTS

PR00401
PR00452
PR00678

PIRSF

SMART

SM00324
SM00252
SM00326

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt