InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Anapc4

Summary

InnateDB Protein

IDBP-164160.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Anapc4

Protein Name

anaphase promoting complex subunit 4

Synonyms

2610306D21Rik; APC4; D5Ertd249e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031072

InnateDB Gene

IDBG-164158 (Anapc4)

Protein Structure

UniProt Annotation

Function

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019903	protein phosphatase binding

Biological Process

GO:0007067	mitotic nuclear division
GO:0030071	regulation of mitotic metaphase/anaphase transition
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0070979	protein K11-linked ubiquitination