Version 5.4
Mus musculus Protein: Nfkbib
Summary
InnateDB Protein IDBP-164193.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nfkbib
Protein Name nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
Synonyms IKappaBbeta; IkB; IKB-beta; IkBb;
Species Mus musculus
Ensembl Protein ENSMUSP00000083012
InnateDB Gene IDBG-164189 (Nfkbib)
Protein Structure
UniProt Annotation
Function Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA- dependent inactivation. Association with inhibitor kappa B- interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
Subcellular Localization Cytoplasm. Nucleus.
Disease Associations
Tissue Specificity Highly expressed in testis followed by spleen.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 24 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 74 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:104752
InterPro IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
PFAM PF00023
PF13606
PF11929
PF12796
PRINTS PR01415
PIRSF
SMART SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q60778
PhosphoSite PhosphoSite-Q60778
TrEMBL D3Z358
UniProt Splice Variant
Entrez Gene 18036
UniGene Mm.220333
RefSeq
MGI ID 1OY3
MGI Symbol Nfkbib
OMIM
CCDS CCDS21054
HPRD
IMGT
EMBL AC171210 AK010218 AK038631 AK156731 CH466593 U19799
GenPept AAC52166 BAB26774 BAC30071 BAE33825 EDL24117 EDL24118

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca