InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gpr68

Summary

InnateDB Protein

IDBP-164207.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gpr68

Protein Name

G protein-coupled receptor 68

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000057510

InnateDB Gene

IDBG-164205 (Gpr68)

Protein Structure

UniProt Annotation

Function

Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer. {ECO:0000269PubMed:17728215, ECO:0000269PubMed:18847331}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in the lung, testis, heart, brain, spleen, thymus, brown fat, small intestine, colon, peripheral blood leukocytes, macrophages, stomach, ovary and white fat but not in the liver, kidney, and skeletal muscle. Expression in the prostate is weak but detectable. {ECO:0000269PubMed:19479052}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0032024	positive regulation of insulin secretion
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0045656	negative regulation of monocyte differentiation
GO:0071467	cellular response to pH
GO:2001206	positive regulation of osteoclast development

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2441763

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR005389 OGR1 sphingosylphosphorylcholine receptor
IPR005464 Psychosine receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR01564
PR01649

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BFQ3