InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccdc88c

Summary

InnateDB Protein

IDBP-164269.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccdc88c

Protein Name

coiled-coil domain containing 88C

Synonyms

0610010D24Rik; AV000935; AW324073; Daple; mKIAA1509;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000068629

InnateDB Gene

IDBG-164265 (Ccdc88c)

Protein Structure

UniProt Annotation

Function

Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit CTNNB1/Beta-catenin stabilization. {ECO:0000269PubMed:14750955}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0030165	PDZ domain binding
GO:0043621	protein self-association

Biological Process

GO:0001932	regulation of protein phosphorylation
GO:0016055	Wnt signaling pathway
GO:0031648	protein destabilization
GO:0051260	protein homooligomerization

Cellular Component

Protein Structure and Domains

PDB ID

MGI:1915589

InterPro

IPR008636 Hook-related protein family
IPR009053 Prefoldin
IPR010978 tRNA-binding arm

PFAM

PF05622

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6VGS5

PhosphoSite

PhosphoSite-Q6VGS5

TrEMBL

UniProt Splice Variant

Entrez Gene

68339

UniGene

RefSeq

NP_080957

MGI ID

MGI Symbol

Ccdc88c

OMIM

CCDS

CCDS26110

HPRD

IMGT

EMBL

AK137260 AY339881

GenPept

AAR08446 BAE23287