InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPIB

Summary

InnateDB Protein

IDBP-16429.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPIB

Protein Name

peptidylprolyl isomerase B (cyclophilin B)

Synonyms

CYP-S1; CYPB; HEL-S-39; OI9; SCYLP;

Species

Homo sapiens

Ensembl Protein

ENSP00000300026

InnateDB Gene

IDBG-16427 (PPIB)

Protein Structure

UniProt Annotation

Function

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Subcellular Localization

Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Disease Associations

Osteogenesis imperfecta 9 (OI9) [MIM:259440]: A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI9 is a severe autosomal recessive form of the disorder. {ECO:0000269PubMed:19781681, ECO:0000269PubMed:20089953}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	54 [view]
Protein-Protein	54 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0032403	protein complex binding
GO:0042277	peptide binding
GO:0044822	poly(A) RNA binding
GO:0051082	unfolded protein binding

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0006457	protein folding
GO:0030198	extracellular matrix organization
GO:0040018	positive regulation of multicellular organism growth
GO:0050821	protein stabilization
GO:0060348	bone development
GO:0061077	chaperone-mediated protein folding

Cellular Component

GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005790	smooth endoplasmic reticulum
GO:0016020	membrane
GO:0032991	macromolecular complex
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome