InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Figla

Summary

InnateDB Protein

IDBP-164312.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Figla

Protein Name

folliculogenesis specific basic helix-loop-helix

Synonyms

bHLHc8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032070

InnateDB Gene

IDBG-164310 (Figla)

Protein Structure

UniProt Annotation

Function

Germ-line specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E- box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters. {ECO:0000269PubMed:11023867}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed only in the oocytes within the ovary and at lower level in the testis. Found in the resting oocytes of the primordial follicle cells, at the periphery of the ovary and in the hilar region. Also detected in growing oocytes, but at lower levels.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0048477	oogenesis