InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gsn

Summary

InnateDB Protein

IDBP-164318.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gsn

Protein Name

gelsolin

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028239

InnateDB Gene

IDBG-164316 (Gsn)

Protein Structure

UniProt Annotation

Function

Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.

Subcellular Localization

Isoform 2: Cytoplasm, cytoskeleton.Isoform 1: Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006915	apoptotic process
GO:0007568	aging
GO:0008154	actin polymerization or depolymerization
GO:0014003	oligodendrocyte development
GO:0016192	vesicle-mediated transport
GO:0030041	actin filament polymerization
GO:0030155	regulation of cell adhesion
GO:0042060	wound healing
GO:0042246	tissue regeneration
GO:0045471	response to ethanol
GO:0048015	phosphatidylinositol-mediated signaling
GO:0051014	actin filament severing
GO:0051593	response to folic acid
GO:0051693	actin filament capping
GO:0060271	cilium morphogenesis
GO:0071276	cellular response to cadmium ion

Cellular Component

GO:0001726	ruffle
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005829	cytosol
GO:0015629	actin cytoskeleton
GO:0030027	lamellipodium
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle