InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hook1

Summary

InnateDB Protein

IDBP-164403.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hook1

Protein Name

hook homolog 1 (Drosophila)

Synonyms

A930033L17Rik; azh;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030306

InnateDB Gene

IDBG-164401 (Hook1)

Protein Structure

UniProt Annotation

Function

Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (By similarity). Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton. {ECO:0000250, ECO:0000269PubMed:12075009}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12075009}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:12075009}. Note=Localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, multivesicular bodies (MVBs), lysosomes, or mitochondria. Often found in close association with microtubules (By similarity). Does not associate with the Golgi complex. During spermiogenesis, it localizes to the manchette in spermatids from steps 8-10. It is also present between the microtubule manchette and the nucleus. During manchette elongation, it is preferentially localized to the nuclear ring of the manchette, whereas the strong localization to the manchette decreases. In more mature spermatids, while the manchette migrates posteriorly, it localizes to punctuates spots. At later stages of spermatid differentiation, the punctuate expression pattern is found at both the attachment site and the proximal end of the elongated manchette. In contrast, it is not present in mature spermatozoa. {ECO:0000250}.

Disease Associations

Note=Defects in Hook1 are the cause of the azh (abnormal spermatozoon head shape) mutant phenotype, which induces spermatozoa with highly abnormal head morphology that differs drastically from the compact and hook-shaped head of the normal sperm, leading to a strong decrease of fertility. {ECO:0000269PubMed:12075009}.

Tissue Specificity

Mainly expressed in testis. {ECO:0000269PubMed:12075009}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0042802	identical protein binding

Biological Process

GO:0007032	endosome organization
GO:0007040	lysosome organization
GO:0007275	multicellular organismal development
GO:0007286	spermatid development
GO:0008333	endosome to lysosome transport
GO:0015031	protein transport
GO:0045022	early endosome to late endosome transport