Version 5.4
Mus musculus Protein: Cyp2c70
Summary
InnateDB Protein IDBP-164451.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cyp2c70
Protein Name cytochrome P450, family 2, subfamily c, polypeptide 70
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000060584
InnateDB Gene IDBG-164449 (Cyp2c70)
Protein Structure
UniProt Annotation
Function Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics (By similarity). {ECO:0000250UniProtKB:P19225}.
Subcellular Localization Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0070330 aromatase activity
Biological Process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005575 cellular_component
GO:0005789 endoplasmic reticulum membrane
Protein Structure and Domains
PDB ID MGI:2385878
InterPro IPR001128 Cytochrome P450
IPR002397 Cytochrome P450, B-class
IPR002401 Cytochrome P450, E-class, group I
IPR002403 Cytochrome P450, E-class, group IV
PFAM PF00067
PRINTS PR00385
PR00359
PR00463
PR00465
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91W64
PhosphoSite PhosphoSite-Q91W64
TrEMBL
UniProt Splice Variant
Entrez Gene 226105
UniGene Mm.418622
RefSeq NP_663474
MGI ID
MGI Symbol Cyp2c70
OMIM
CCDS CCDS37976
HPRD
IMGT
EMBL AY227736 BC016494 BC022151 BC023894 BC025822 BC034831
GenPept AAH16494 AAH22151 AAH23894 AAH25822 AAH34831 AAP55509

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca