Version 5.4
Homo sapiens Protein: CSNK1G1
Summary
InnateDB Protein IDBP-16459.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CSNK1G1
Protein Name casein kinase 1, gamma 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000305777
InnateDB Gene IDBG-16457 (CSNK1G1)
Protein Structure
UniProt Annotation
Function Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN. {ECO:0000250, ECO:0000269PubMed:21680713}.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0016055 Wnt signaling pathway
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR022247 Casein kinase 1 gamma C-terminal
PFAM PF00069
PF07714
PF12605
PRINTS PR00109
PIRSF
SMART SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HCP0
PhosphoSite PhosphoSite-Q9HCP0
TrEMBL U3KQP7
UniProt Splice Variant
Entrez Gene 53944
UniGene Hs.646508
RefSeq NP_071331
HUGO HGNC:2454
OMIM 606274
CCDS CCDS10192
HPRD
IMGT
EMBL AB042562 AB042563 AC087632 AC110054 AL832551 BC017236 BC130613 BC136504 CH471082
GenPept AAH17236 AAI30614 AAI36505 BAB17838 BAB17839 CAI46142 EAW77670 EAW77671 EAW77673 EAW77676 EAW77678

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca