Version 5.4
Mus musculus Protein: Pbxip1
Summary
InnateDB Protein IDBP-164657.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pbxip1
Protein Name pre-B-cell leukemia transcription factor interacting protein 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000040429
InnateDB Gene IDBG-164655 (Pbxip1)
Protein Structure
UniProt Annotation
Function Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Note=Shuttles between the nucleus and the cytosol. Mainly localized in the cytoplasm, associated with microtubules. Detected in small amounts in the nucleus (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID MGI:2441670
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3TVI8
PhosphoSite PhosphoSite-Q3TVI8
TrEMBL D3Z2F0
UniProt Splice Variant
Entrez Gene 229534
UniGene Mm.65906
RefSeq NP_666243
MGI ID
MGI Symbol Pbxip1
OMIM
CCDS CCDS17510
HPRD
IMGT
EMBL AC171273 AK028858 AK159422 AK159448 AK159633 AK160103 AK170318 BC026838 BC027771 BC034200
GenPept AAH26838 AAH27771 AAH34200 BAC26157 BAE35070 BAE35092 BAE35247 BAE35630 BAE41713

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca