InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tia1

Summary

InnateDB Protein

IDBP-164672.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tia1

Protein Name

cytotoxic granule-associated RNA binding protein 1

Synonyms

2310050N03Rik; AI256674; mTIA-1; TIA-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000093425

InnateDB Gene

IDBG-164670 (Tia1)

Protein Structure

UniProt Annotation

Function

Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasmic granule {ECO:0000250}. Nucleus. Note=Accumulates in cytoplasmic stress granules (SG) following cellular damage. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0017091	AU-rich element binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006915	apoptotic process
GO:0017148	negative regulation of translation
GO:0042036	negative regulation of cytokine biosynthetic process
GO:0048024	regulation of mRNA splicing, via spliceosome