InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RTN4R

Summary

InnateDB Protein

IDBP-1647.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RTN4R

Protein Name

reticulon 4 receptor

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000043402

InnateDB Gene

IDBG-1645 (RTN4R)

Protein Structure

UniProt Annotation

Function

Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. Acts in conjunction with RTN4 and LIGO1 in regulating neuronal precursor cell motility during cortical development (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Lipid-anchor, GPI-anchor.

Disease Associations

Tissue Specificity

Widespread in the brain but highest levels in the gray matter. Low levels in heart and kidney not expressed in oligodendrocytes (white matter).

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0007409	axonogenesis
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0050770	regulation of axonogenesis
GO:0050771	negative regulation of axonogenesis