Version 5.4
| Mus musculus Protein: Cckar | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||||
| InnateDB Protein | IDBP-164712.6 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | Cckar | ||||||||||
| Protein Name | cholecystokinin A receptor | ||||||||||
| Synonyms | AW106902; | ||||||||||
| Species | Mus musculus | ||||||||||
| Ensembl Protein | ENSMUSP00000031093 | ||||||||||
| InnateDB Gene | IDBG-164710 (Cckar) | ||||||||||
| Protein Structure |
|
||||||||||
| UniProt Annotation | |||||||||||
| Function | Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). {ECO:0000250}. | ||||||||||
| Subcellular Localization | Cell membrane; Multi-pass membrane protein. | ||||||||||
| Disease Associations | |||||||||||
| Tissue Specificity | |||||||||||
| Comments | |||||||||||
| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
|
||||||||||
| Gene Ontology | |||||||||||
Molecular Function |
|
||||||||||
| Biological Process |
|
||||||||||
| Cellular Component |
|
||||||||||
| Protein Structure and Domains | |||||||||||
| PDB ID | MGI:99478 | ||||||||||
| InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like IPR000314 Gastrin receptor IPR000596 Cholecystokinin receptor type A IPR000611 Neuropeptide Y receptor family IPR009126 Cholecystokinin receptor IPR015276 Cholecystokinin A receptor, N-terminal IPR017452 GPCR, rhodopsin-like, 7TM IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx IPR019430 7TM GPCR, serpentine receptor class x (Srx) |
||||||||||
| PFAM |
PF00001
PF09193 PF10320 PF10328 |
||||||||||
| PRINTS |
PR00237
PR00527 PR00524 PR01012 PR01822 |
||||||||||
| PIRSF | |||||||||||
| SMART | |||||||||||
| TIGRFAMs | |||||||||||
| Post-translational Modifications | |||||||||||
| Modification | |||||||||||
| Cross-References | |||||||||||
| SwissProt | O08786 | ||||||||||
| PhosphoSite | PhosphoSite-O08786 | ||||||||||
| TrEMBL | Q3TPL0 | ||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 12425 | ||||||||||
| UniGene | Mm.417341 | ||||||||||
| RefSeq | NP_033957 | ||||||||||
| MGI ID | |||||||||||
| MGI Symbol | Cckar | ||||||||||
| OMIM | |||||||||||
| CCDS | CCDS19293 | ||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | AF015959 AF015960 AF015961 AF015962 AF015963 AK004730 AK164301 BC020534 D85605 | ||||||||||
| GenPept | AAC07949 AAH20534 BAA20068 BAB23512 BAE37726 | ||||||||||