Version 5.4
Mus musculus Protein: Pou2af1
Summary
InnateDB Protein IDBP-164754.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pou2af1
Protein Name POU domain, class 2, associating factor 1
Synonyms Bob-1; BOB.1; Bob1; OBF-1; OBF.1; OCA-B; OCAB;
Species Mus musculus
Ensembl Protein ENSMUSP00000034554
InnateDB Gene IDBG-164752 (Pou2af1)
Protein Structure
UniProt Annotation
Function Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity B-cell specific.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:105086
InterPro IPR015389 POU, class 2, associating factor 1
PFAM PF09310
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q64693
PhosphoSite PhosphoSite-Q64693
TrEMBL Q542H4
UniProt Splice Variant
Entrez Gene 18985
UniGene Mm.897
RefSeq NP_035266
MGI ID
MGI Symbol Pou2af1
OMIM
CCDS CCDS23176
HPRD
IMGT
EMBL AK088587 AK135080 CH466522 U43788 Z54283
GenPept AAC52618 BAC40437 BAE22412 CAA91058 EDL25775

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca